09:00  00:33:41

Welcome remarks

Amos Korczyn, Israel
Exuperio Diez Tejedor, Spain

09:30  00:23:27

The role of fungi in the etiology of multiple sclerosis

Julian Benito-Leon, Spain

10:00  00:30:41

Immune checkpoint inhibitors and neurological disease

Olaf Stuve, USA

10:30  00:28:10

What´s next: Immunotherapy of MS after the anti-CD20s

Antonio García Merino, Spain

11:30  00:31:23

Is imagination a distinct metacognitive process with its own neurobiological substrate?

Daniel Drubach,USA

12:00  00:26:59

The secrets of FXTAS

Sharon Hassin-Baer, Israel

12:30  00:28:15

The new world of focused ultrasound to treat neurodegenerative diseases

Jose Obeso, Spain

13:45  00:30:20

Epilepsy genetics and precision therapies – trials and tribulations

Samuel Berkovic, Australia

14:15  00:31:09

Gene therapy in epilepsy

Matthew Walker, UK

14:45  00:31:22

How will new devices impact the diagnosis and treatment of seizures?

Michael Sperling, USA

15:30  00:29:33

Beyond amyloid, the sweet trail to neuroprotection

Stefano Sensi, Italy

16:00  00:28:55

Tau seeding and disease progression in AD

Isidro Ferrer, Spain

16:30  00:30:42

Neuropathological basis of sleep disorders in neurodegenerative diseases

Lea Grinberg, USA/Brazil

17:00  00:55:43

Debate: Is preclinical AD a useful term?

Host: Joseph Masdeu, USA
Yes: David Knopman, USA
No: Amos Korczyn, Israel
Discussions and rebuttals

18:00  00:33:02

Cajal, the neuron theory and the golden era for artistic creativity in neuroscience

Javier DeFelipe, Spain

18:30  00:27:43

Musical Interlude

08:30  00:42:15

Will neurofilaments light (NFL) serum levels be the gold standard for monitoring MS progression, replacing MRI?

Host: Laszlo Vecsei, Hungary
Yes: Georgina Arrambide, Spain
No: Georgina Arrambide, Spain
Discussions and rebuttals

09:20  00:51:28

Evoked potentials (EP’s) still have a role in diagnosing MS and monitoring disease progression.

Host: Jera Kruja, Albania
Pro: Letizia Leocani, Italy
Con: Bianca Weinstock-Guttman, USA
Discussion and rebuttals

10:25  00:51:09

Will neurofilaments light (NFL) serum levels be the gold standard for monitoring MS progression, replacing MRI?

Host: Mark Freedman, Canada
Yes: Mark Freedman, Canada
No: Joab Chapman, Israel
Discussions and rebuttals

11:15  00:48:40

Does primary progressive MS (PPMS) have the same immunopathogenesis as secondary progressive MS (SPMS)?

Host: Ralf Linker, Germany
Yes: Ralf Linker, Germany
No: Jacek Losy, Poland
Discussions and rebuttals

14:15  00:38:09

Should therapy be initiated in clinically isolated syndrome (CIS) cases not having oligoclonal bands (OCB)?

Host: Larysa Sokolova, Ukraine
Yes: Klaus Schmierer, UK
No: Marcin Mycko, Poland
Discussions and rebuttals

14:55  00:40:54

CSF is still important in the diagnosis of MS.

Host: Uros Rot, Slovenia
Pro: Konrad Rejdak, Poland
Con: Brian Weinshenker, USA
Discussions and rebuttals

16:00  01:10:23

Is the switch from brand-name to generic drugs in MS safe and justified?

Host: Ron Milo, Israel
Yes: Ovidiu Bajenaru, Romania
No: Klaus Schmierer, UK
Discussion and rebuttals

16:50  00:50:15

Cognitive dysfunction is amenable to MS specific disease modifying drugs (DMD).

Host: Anastasios Orologas, Greece
Pro: Bianca Weinstock Guttman, USA
Con: Friedemann Paul, Germany
Discussions and rebuttals

17:40  00:51:36

Round table: The reasons of MS misdiagnosis.

Hosts : Oscar Fernandez, Spain & Olaf Stuve, USA
Speakers: Mark Freedman, Canada; Ralf Linker, Germany; Ron Milo, Israel; Bianca Weinstock Guttman, USA

07:30  00:09:41

Overlap of the Pitt–Hopkins and Lennox-Gastaut syndromes

Biljana Dapic Ivancic, Croatia

07:40  00:16:05

Prevalence of headache among patients with epilepsy

Ewa Czapinska-Ciepiela, Poland

07:50  00:13:09

Development of patients` e-registry and electronic medical records (EMR) as cost-effective management system for epilepsy - the pilot study in Georgia

Sofia Kasradze, Georgia

08:30  00:53:55

Should we routinely prescribe immune modulatory therapy to patients with refractory adult-onset epilepsy who also develop psychiatric or cognitive impairment?

Host: Dana Ekstein, Israel
Pro: William Theodore, USA
Con: Martin Holtkamp, Germany
Discussion and rebuttals

09:20  01:03:07

Are non-epileptic seizures really psychogenic?

Host: Alla Guekht, Russia
Yes: Curt W LaFrance, USA
No: Amos Korczyn, Israel
Discussion and rebuttals

10:25  00:41:13

Should antiepileptic drugs (AED) be pushed to high doses and levels before switching to or adding a new drug?

Host: Manuel Toledo, Spain
Yes: Elinor Ben-Menachem, Sweden
No: Martin Brodie, UK
Discussion and rebuttals

11:15  00:53:42

Should vagus nerve stimulation (VNS) be recommended early in the course of illness when seizures fail to respond to medication and cause falling or generalize?

Host: Zeljka Petelin Gadze, Croatia
Pro: Antonio Gil-Nagel, Spain
Con: Ivan Rektor, Czech Republic
Discussion and rebuttals

14:15  00:55:32

Should women breastfeed if they take anticonvulsant medication?

Host: Ilan Blatt, Israel
Yes: Martin Brodie, UK
No: Alla Guekht, Russia
Discussion and rebuttals

14:45  00:46:12

Should we prescribe medical marijuana for adult patients with drug-resistant epilepsy?

Host: Martin Holtkamp, Germany
Yes: Elson So, USA
No: Ilan Blatt, Israel
Discussion and rebuttals

16:00  00:47:58

Are genetic data likely to be of major importance in the personalized treatment of epilepsy patients?

Host: Michael Sperling, USA
Likely: Samuel Berkovic, Australia
Unlikely: William Theodore, USA
Discussion and rebuttals

16:50  00:52:06

Should MRI scans undergo routine post-processing if visual inspection does not show abnormalities in people with epilepsy?

Host: Manuel Toledo, Spain
Yes: Matthias Koepp, UK
No: Elson So, USA
Discussion and rebuttals

17:40  01:04:50

Epilepsy Cases

Michael Sperling, USA, and Manjari Tripathi, India

07:00  00:10:39

A provocative test as a new approach to preclinical diagnostics of Parkinson's disease and to assessment of degradation of nigrostriatal dopaminergic system

Michael Ugryumov, Russia

07:10  00:11:51

Study of olfactory function in patients with Parkinson disease and healthy people

Denis Pokhabov, Russia

07:20  00:08:26

Atypical parkinsonian tauopathies – different diseases?

Piotr Alster, Poland

07:30  00:09:45

Subjective and objective motor function is associated with prodromal Parkinson's disease: a population based cohort study

Georgia Xiromerisiou, Greece

08:00  00:48:46

DAT imaging with SPECT or PET in parkinsonism: which one to choose?

Host: Javier Arbizu, Spain
Pro SPECT: Pierre Payoux, France
Pro PET: Andrea Varrone, Sweden
Discussion and rebuttals

08:50  00:49:33

Wearable technology devices will replace clinical PD motor assessments.

Host: Alvaro Sanchez Ferro, Spain
Pro: Fatta Nahab, USA
Con: Pablo Martinez-Martin, Spain
Discussion and rebuttals

09:40  00:53:34

Neurogenic orthostatic hypotension is a major cause of disability in PD.

Host: Stuart Isaacson, USA
Pro: David Goldstein, USA
Con: Nestor Galvez Jimenez, USA
Discussion and rebuttals

10:45  00:49:13

Treating PD psychosis early improves long-term outcomes.

Host: Nestor Galvez Jimenez, USA
Pro: Daniel Kremens, USA
Con: Jaime Kulisevsky Bojarski, Spain
Discussion and rebuttals

11:35  00:48:33

Gastrointestinal dysmotility is the major cause of motor fluctuations in PD.

Host: Bogdan Popescu, Romania
Pro: Stuart Isaacson, USA
Con: Esther Cubo, Spain
Discussion and rebuttals

13:25  00:48:29

Medical treatment of dyskinesias is as effective as deep brain stimulation (DBS)

Host: Fiona Gupta, USA
Pro: Rajesh Pahwa, USA
Con: Sharon Hassin-Baer, Israel
Discussion and rebuttals

14:15  00:41:21

Tardive dyskinesia (TD) remains a common consequence of second generation (or current) antipsychotics.

Host: Pedro J. Garcia Ruiz, Spain
Yes: Laxman Bahroo, USA
No: Cristian Falup-Pecurariu, Romania
Discussion and rebuttals

15:20  00:40:27

Off time will disappear with longer acting levodopa (LD) formulations.

Host: Laxman Bahroo, USA
Pro: Diego Santos Garcia, Spain
Con: Jaroslaw Slawek, Poland
Discussion and rebuttals

16:10  00:37:55

Subcutaneous apomorphine infusion should be used before other advanced therapies.

Host: Stuart Isaacson, USA
Pro: Mark Lew, USA
Con: Per Odin, Sweden
Discussion and rebuttals

17:00  00:38:25

Development of non-dopaminergic therapies is a greater unmet need than dopaminergic treatments.

Host: Fiona Gupta, USA
Pro: Abdelhamid Benazzouz, France
Con: Ilana Schlesinger, Israel
Discussion and rebuttals

17:50  00:43:26

What should be the main therapeutic target in Huntington's disease (HD)?

Host: Jaime Kulisevsky Bojarski, Spain
Chorea: Esther Cubo, Spain
Bradykinesia and axial impairment: Pedro J. Garcia Ruiz, Spain
Discussion and rebuttals

08:00  00:54:13

Cognitive-behavioral therapy and biofeedback training are as effective as preventive medication in some patients.

Host: Robert Shapiro, USA
Yes: Steve Baskin, USA
No: Mark Braschinsky, Estonia
Discussion and rebuttals

08:50  00:55:59

Monoclonal antibodies to CGRP will become first line treatment not only for migraine but also for episodic cluster headache.

Host: Christian Lampl, Austria
Yes: Lars Edvinsson, Sweden
No: Jose Miguel Lainez. Spain
Discussion and rebuttals

09:40  00:51:40

Electrical stimulation will replace medications for the treatment of cluster headache.

Host: Jack Schim, USA
Yes: Licia Grazzi, Italy
No: Giorgio Lambru, UK
Discussion and rebuttals

10:45  00:22:59

Update on monoclonal antibody therapies and CGRP receptor antagonists in primary headache

Messoud Ashina, Denmark

11:15  00:29:32

Pipeline in headache treatment

Alan Rapoport, USA

11:45  00:11:37

Chronic headache - clinical evaluation of the chronic inflammatory state with acute inflammation

Maria Angels Carrera, Spain

11:55  00:07:41

Application of the cluster headache severity scale in a Korean cohort of cluster headache

Soo-Jin Cho, Korea

13:25  00:58:00

Migraine with aura and migraine without aura are the same disease.

Host: Dimos Mitsikostas, Greece
Yes: Isabel Pavao Martins, Portugal
No: Margarita Sanchez-del-Rio, Spain
Discussion and rebuttals

14:15  00:48:42

Does the blood brain barrier (BBB) open during a migraine attack?

Host: Jose Miguel Lainez, Spain
Yes: Pablo Irimia Sieria, Spain
No: Messoud Ashina, Denmark
Discussion and rebuttals

15:20  00:51:07

Computers can diagnose cluster headache better than the average doctor

Host: Min Kyung Chu, South Korea
Yes: Robert Cowan, USA
No: Giorgio Lambru, UK
Discussion and rebuttals

16:!0  00:50:00

hunderclap headache: Do we need more than head CT and lumbar puncture?

Host: Robert Cowan, USA
Yes: Christian Lampl, Austria
No: Julio Pascual, Spain
Discussion and rebuttals

17:00  00:51:43

Medical cannabis is effective in chronic headache

Host: Manjit Matharu, UK
Yes: Brian McGeeney, USA
No: Dimos Mitsikostas, Greece
Discussion and rebuttals

17:50  00:16:06

Reimagine Migraine

Germán Latorre González, Spain

18:05  00:41:12

Placebo and nocebo in headaches

Dimos Mitsikostas, Greece